*Shown is the least-squares mean change from baseline to the time of each trial assessment in the Hammersmith Functional Motor Scale–Expanded (HFMSE) score in the final analysis. HFMSE scores range from 0 to 66, with higher scores indicating better motor function; a change in the HFMSE score of at least 3 points is considered to be clinically meaningful. Error bars indicate standard errors.1
age 6 years*Later-onset (Type II) SMA
treated with SPINRAZA®
~4 years as of 9/18
1. SPINRAZA® Summary of Product Characteristics.